Combinatorial approaches to harmacophori
โ
Mikhail F. Gordeev
๐
Article
๐
1998
๐
John Wiley and Sons
๐
English
โ 183 KB
๐ 2 views
An efficient solid-phase synthesis of 3,1benzoxazine-4-ones is described. Immobilized amino acid based functionalized urea derivatives 2 undergo a high yielding heterocyclization under mild conditions in presence of coupling reagents (DIC, TsCl/Py, or Ac 2 O) to afford 3,1-benzoxazine-4ones 6. The m