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Combinatorial synthesis of heterocycles: Solid phase synthesis of 2-arylquinoline-4-carboxylic acid derivatives

โœ Scribed by Ariamala Gopalsamy; Peter V. Pallai


Book ID
104256201
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
179 KB
Volume
38
Category
Article
ISSN
0040-4039

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Solid-phase combinatorial synthesis of 4
โœ Mui Mui Sim; Cheng Leng Lee; A. Ganesan ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 192 KB

Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces 13-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, lead