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Combinatorial Solid-Phase Synthesis of Hapalosin Mimetics 1,2

✍ Scribed by Olsen, Jacob A.; Jensen, Knud J.; Nielsen, John


Book ID
127371335
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
104 KB
Volume
2
Category
Article
ISSN
1520-4766

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Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces 13-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, lead