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Solid-phase combinatorial synthesis of benzothiazole and 2,3-dihydro-[1,5]-benzothiazepine derivatives

✍ Scribed by Cheng Leng Lee; Yulin Lam; Soo-Ying Lee


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
76 KB
Volume
42
Category
Article
ISSN
0040-4039

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Solid phase synthesis of 1,4-benzothiaze
✍ Adel Nefzi; Nhi A Ong; Marc A Giulianotti; John M Ostresh; Richard A Houghten πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 199 KB

The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro-5-nitro-benzoic acid followed by a reductive aikylation and an intra molecular cyclization, is described.