The actinomycin antibiotics bind to nucleic acids via both intercalation and hydrogen bonding. We found this 'double-action attack' mechanism very attractive in our search for a novel class of nucleic acid binders. A highly convergent, solid-phase synthetic strategy has been developed for a class of
✦ LIBER ✦
Combinatorial solid-phase synthesis of balanol analogues
✍ Scribed by John Nielsen; Lars O. Lyngsø
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 205 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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