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Clinical trial and pharmacokinetics of carboplatin 560 mg/m2 in children

✍ Scribed by Doz, Francois ;Brugières, Laurence ;Bastian, Gérard ;Quintana, Erica ;Lemerle, Jean ;Zucker, Jean-Michel

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
596 KB
Volume
18
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

We report a clinical trial with carboplatin (CBDCA) in 15 children with malignant solid tumors recurrent after or resistant to conventional treatment. Based on previous phase I clinical trials, these children were given a dose of CBDCA 560 mg/m^2^ by intravenous infusion every 4 weeks.

The study includes a pharmacokinetic analysis of CBDCA in three patients. This clinical trial shows the feasibility of this CBDCA schedule, even after high cumulative doses of previous chemotherapy. As expected the main toxicity was hematologic but the risk of renal and ototoxicity is not excluded and these functions have still to be monitored when this relatively high dose of CBDCA chemotherapy is used.

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