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Clinical trial and pharmacokinetic study of combination paclitaxel and carboplatin in patients with epithelial ovarian cancer

✍ Scribed by Ritsu Yamamoto; Masanori Kaneuchi; Masashi Nishiya; Yukiharu Todo; Mahito Takeda; Kazuhira Okamoto; Hiroaki Negishi; Noriaki Sakuragi; Seiichiro Fujimoto; Takeshi Hirano


Publisher
Springer
Year
2002
Tongue
English
Weight
95 KB
Volume
50
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c