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Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy

โœ Scribed by Chau-Ting Yeh; Rong-Nan Chien; Chia-Ming Chu; Yun-Fan Liaw

Book ID
111721245
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
316 KB
Volume
31
Category
Article
ISSN
0270-9139

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Lamivudine is a potent inhibitor of hepatitis B virus (HBV) replication, but its long-term use may be associated with HBV tyrosine-methionine-aspartate-aspartate (YMDD) motif mutation. To examine the clinical features and course after emergence of YMDD mutants, 55 patients who received lamivudine th