Is it safe to stop lamivudine after the emergence of YMDD mutants during lamivudine therapy for chronic hepatitis B?
โ Scribed by V.W.S. Wong; H.L.Y. Chan; M.L. Wong; Nancy Leung
- Book ID
- 118565542
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 97 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0168-8278
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Although hepatitis B virus (HBV) precore-stop mutant (nonsense mutation at codon 28) is usually isolated from patients with hepatitis B e antigen (HBeAg)-negative hepatitis, it is unclear whether the mutant is the cause of the hepatitis flare or it is a consequence of necroinflammation. Using the am
Treatment of hepatitis B virus (HBV) with lamivudine is effective in suppressing virus replication and results in reduced inflammatory activity. However, the emergence of lamivudine-resistant mutant virus, with amino acid substitution in the YMDD motif of DNA polymerase, has been reported. We report