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Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine

✍ Scribed by Nao Kurashige; Naoki Hiramatsu; Kazuyoshi Ohkawa; Tsugiko Oze; Yuko Inoue; Mika Kurokawa; Takayuki Yakushijin; Takumi Igura; Shinichi Kiso; Tatsuya Kanto; Tetsuo Takehara; Shinji Tamura; Akinori Kasahara; Masahide Oshita; Taizo Hijioka; Kazuhiro Katayama; Harumasa Yoshihara; Eijirou Hayashi; Yasuharu Imai; Michio Kato; Norio Hayashi


Book ID
118087916
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
120 KB
Volume
38
Category
Article
ISSN
1386-6346

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Lamivudine (LAM) is a nucleoside analogue widely used for the treatment of chronic hepatitis B virus (HBV) infection. Emergence of resistant strains with amino acid substitutions in the tyrosine-methionine-aspartate-aspartate (YMDD) motif of reverse transcriptase is a serious problem in patients on