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The role of HBV genotype in the emergence of YMDD variants in chronic hepatitis B patients treated with lamivudine

โœ Scribed by C.A. Valdes; M. Buti; X. Costa; R. Jardi; F. Rodriguez-F.; I. Mesas; R. Esteban; J. Guardia

Book ID
117372748
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
162 KB
Volume
38
Category
Article
ISSN
0168-8278

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Lamivudine (LAM) is a nucleoside analogue widely used for the treatment of chronic hepatitis B virus (HBV) infection. Emergence of resistant strains with amino acid substitutions in the tyrosine-methionine-aspartate-aspartate (YMDD) motif of reverse transcriptase is a serious problem in patients on