cis-Platinum and 5-fluorouracil as initial therapy in advanced epidermoid cancers of the head and neck

✍ Scribed by Weaver, Arthur ;Fleming, Susan ;Vandenberg, Henry ;Drelichman, Anibal ;Jacobs, John ;Kinzie, Jeannie ;Loh, John J.-K. ;Al-Sarraf, Muhyi

• Publisher: Wiley (John Wiley & Sons)
• Year: 1982
• Weight: 397 KB
• Volume: 4
• Category: Article
• ISSN: 0148-6403
• DOI: 10.1002/hed.2890040504

✦ Synopsis

Abstract

A total of 44 patients with previously untreated Stage IV squamous cell carcinomas of the head and neck were treated with a combination of cis‐platinum (100 mg/sq m) and 96‐hour infusion of 5‐fluorouracil (5‐FU) (1,000 mg/sq m/day) in two courses or with cis‐platinum (100 mg/sq m) and 120‐hour infusion of 5‐FU (1,000 mg/sq m/day) in three courses. In the 26 patients receiving the two course regimen, the tumor response rate was 88.5%. In five of the 26 patients complete disappearance of the tumor was achieved; partial remission was obtained in 18 of 26 patients. The main side effects were nausea and vomiting (70%), leukopenia (27%), and mild‐to‐moderate renal toxicity (27%). In the 18 patients who received the three course regimen of 5‐FU and cis‐platinum, there were 11 (61%) complete responses, 6 (33%) partial responses, and 1 (6%) minimal response. The incidence of complete response was increased with each course given. No added toxicity was observed with surgery or radiotherapy.