One hundred and twenty-seven patients with advanced or recurrent squamous cell carcinoma of the head and neck (HNC) were randomized to treatment with methotrexate (MTX) followed 1 hour later by 5-fluorouracil (5-FU) (sequence MF), or 5-fluorouracil followed after 1 hour by methotrexate (sequence FM)
Sequential trial of initial chemotherapy for advanced cancer of the head and neck: DDP versus DDP + 5-fluorouracil
β Scribed by Paul Coninx; Salvator Nasca; Daniela Lebrun; Xavier Panis; Patrick Lucas; Edouard Garbe; Michel Legros
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 534 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Patients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96-h 5-fluorouracil (5-FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)-5-FU. Thirt
## Abstract A total of 44 patients with previously untreated Stage IV squamous cell carcinomas of the head and neck were treated with a combination of cisβplatinum (100 mg/sq m) and 96βhour infusion of 5βfluorouracil (5βFU) (1,000 mg/sq m/day) in two courses or with cisβplatinum (100 mg/sq m) and 1
There were 79 patients with squamous Cell head and neck cancer randomized to receive simultaneous or 1 hour sequential methotrexate-5 fluorouracil (MTX-5-FU) chemotherapy: 47 patients were previously untreated and 32 patients had recurrent disease. The treatment groups were comparable for important