A combination of cisplatin, methotrexate, bleomycin, and vincristine (CABO) was assessed in advanced epidermoid head and neck cancer. Among 72 patients with recurrent or metastatic disease and measurable lesions, there were 9 complete and 27 partial responses for an overall response rate of 50%. The
Sequential methotrexate and 5-fluorouracil with bleomycin and cisplatin in the chemotherapy of advanced squamous cancer of the head and neck
โ Scribed by Steven E. Vogl; Arnold Komisar; Barry H. Kaplan; Paul F. Engstrom; Omar H. Kasule; Leo Stolbach; Harvey Lerner; Franco Muggia
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 520 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
Patients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96-h 5-fluorouracil (5-FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)-5-FU. Thirt
## For the EORTC Head and Neck Cooperative Group A total of 185 eligible patients with advanced inoperable squamous cell carcinoma of the head and neck were randomized into two groups; the cisplatin, methotrexate, bleomycin, and vincristine (CABO) group received cisplatin (50 mg/m2; day 4), methot