Cisplatin and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck
โ Scribed by Julie A. Kish; Arthur Weaver; John Jacobs; Glenn Cummings; Muhyi Al-Sarraf
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 754 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi
## Abstract A total of 44 patients with previously untreated Stage IV squamous cell carcinomas of the head and neck were treated with a combination of cisโplatinum (100 mg/sq m) and 96โhour infusion of 5โfluorouracil (5โFU) (1,000 mg/sq m/day) in two courses or with cisโplatinum (100 mg/sq m) and 1
## Abstract ## Background. In locally advanced head and neck cancer, concurrent chemoradiotherapy (CRT) with combined 5โfluorouracil (5โFU) and cisplatin has increased acute toxicities as well as survival. Onceโweekly chemotherapeutic administration schedule may reduce severe toxicities. Thus, we