Chromosomal control of malignancy in tumors from cells transformed by polyoma virus

✍ Scribed by Toshiyuki Yamamoto; Makoto Hayashi; Zelig Rabinowitz; Leo Sachs

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: French
• Weight: 651 KB
• Volume: 11
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910110307

✦ Synopsis

The chromosome banding pattern has been analyzed in clones of male and female golden hamster cells independently transformed by polyoma virus and tumors derived from these cells. All the tumors showed either a loss of a piece of chromosome S3 or a gain of a piece or a whole chromosome of 5,. An additional 7, chromosome in one line of transformed cells was lost in the tumors derived from this line. The results support our gene balance model of malignancy and indicate that genes of expression of malignancy in these cells were located on chromosome S6 and that genes for suppression of malignancy were located on a piece of chromosome 5, and on chromosome 72. All transformed lines and their tumors showed a loss of apiece of one or both X chromosomes in male and female cells, respectively. This loss of a piece of X chromosome was also found in non-malignant revertants from polyoma-transformed cells, so that this change in the X chromosome was not specific for malignant cells.