𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Neoplastic transformation of hamster brain cells in vitro by polyoma virus

✍ Scribed by C. De Micco; M. F. Tripier; J. Hassoun; C. Lipcey; G. Meyer; M. Toga

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
936 KB
Volume
21
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The transformation of cultivated hamster brain cells by polyoma virus is reported. The transformed cell line contained polyoma virus‐specific nuclear, surface and transplantation antigens. Subcutaneous and intracranial inoculations revealed high tumorigenicity of the cells. Brain‐specific S 100 protein was found in these tumors with immuno‐peroxidase staining, suggesting that they were of a nervous nature. Both in vivo and in vitro, the cells had glial features as studied by phase contrast, light and electron microscopy. Type‐H virus‐like particles were found in the tumor cells and might have played a role in the viral transformation.

📜 SIMILAR VOLUMES

Neoplastic differentiation: Interaction
Neoplastic differentiation: Interaction of simian virus 40 and polyoma virus with murine teratocarcinoma cells in vitro
✍ D. E. Swartzendruber; J. M. Lehman 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 738 KB

## Abstract The host‐virus interactions of Simian virus 40 (SV^40^) and polyoma virus (Py) with cell lines established from a teratocarcinoma were studied. The cells utilized in this study were the multipotential stem cell of the teratocarcinoma, embryonal carcinoma, and differentiated cells derive

Chromosomal control of malignancy in tum
Chromosomal control of malignancy in tumors from cells transformed by polyoma virus
✍ Toshiyuki Yamamoto; Makoto Hayashi; Zelig Rabinowitz; Leo Sachs 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 651 KB

The chromosome banding pattern has been analyzed in clones of male and female golden hamster cells independently transformed by polyoma virus and tumors derived from these cells. All the tumors showed either a loss of a piece of chromosome S3 or a gain of a piece or a whole chromosome of 5,. An addi

Further manifestations of abortive trans
Further manifestations of abortive transformation of bhk 21 cells by polyoma virus
✍ Joyce Taylor-Papadimitriou; M. G. P. Stoker; P. Riddle 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 678 KB

## Abstract Abortive transformation of layer cultures of BHK 21 cells by polyoma virus has been studied using serum‐depleted medium. High doses of partially purified infectious virus, in the absence of serum, stimulate the majority of the cells to synthesize DNA while empty capsids do not. The onse

Activation of carcinogenic polycyclic hy
Activation of carcinogenic polycyclic hydrocarbons in polyoma-virus-transformed cells as a prerequisite for polyoma virus induction
✍ Eliezer Huberman; Marian Fogel 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 509 KB

## Abstract Polyoma‐virus (PV)‐transformed cell clones, which are inducible for virus synthesis by various physical and chemical agents, metabolize the chemically non‐reactive carcinogen benzo (a)pyrene (BP) into water‐soluble products. In cultures of such clones, which metabolize BP to a level of

Neoplastic transformation induced by fur
Neoplastic transformation induced by furylfuramide and nitromethylfuran of embryonic hamster cells in tissue culture
✍ Yoshisuke Nishi; Masako Taketomi; Naomichi Inui 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 739 KB

## Abstract Secondary cultures of Syrian hamster embryonic fibroblasts were tested for transformation and neoplastic properties after exposure __in vitro__ to furylfuramide (AF‐2) and other nitrofurans. Typical morphological transformation was seen in five of six cultures between 30 and 186 days fo