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The stimulation of 2-deoxy-D-glucose transport in control and virus-transformed cells by ethidium bromide

✍ Scribed by Gerald Soslau; Margit M. K. Nass

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
848 KB
Volume
86
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Recently we demonstrated that ethidium bromide altered the plasma and subcellular membrane glycoproteins in control and virus transformed cells. It is reported here that ethidium bromide also stimulated the membrane associated process of sugar transport. The K~m~ of the virus transformed cells and the ethidium bromide treated cells is the same as that of the control cells while the maximum velocity as compared to the control cells is significantly increased. The transport of 2‐deoxy‐D‐glucose was inhibited by glucose, cytochalasin B and neuraminidase but was unaffected by variations in cell density or pH of the incubation medium.

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