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ChemInform Abstract: Total Synthesis of Brevetoxin A. Part 3. Construction of GHIJ and BCDE Ring Systems.

✍ Scribed by K. C. Nicolaou; et al. et al.


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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Total Synthesis of Brevetoxin A: Part 2:
✍ K. C. Nicolaou; Paul A. Wallace; Shuhao Shi; Michael A. Ouellette; Mark E. Bunna πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 252 KB πŸ‘ 1 views

Our second generation strategy for the total synthesis of brevetoxin A involved dissection of the molecule at the ring F oxocene. Synthetically, the F ring formation was expected to occur through Wittig coupling of requisite polycyclic fragments 2 and 3, followed by a hydroxy dithioketal cyclization