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ChemInform Abstract: Synthesis of 2[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-yl)propyl]-4- [4-tetrafluoropropoxyphenyl]-3-(2H,4H)-1,2,4-triazol-3-thione — A Novel and Potent Azole Antifungal Agent.

✍ Scribed by Jitendra A. Sattigeri; Sachin Sethi; Mohammad Salman

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

Starting from the known epoxy alcohol (I), a new strategy for the synthesis of the potent fungicide (IX) in multigram quantities is developed.

📜 SIMILAR VOLUMES

ChemInform Abstract: Optically Active An
ChemInform Abstract: Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones.
✍ Kitazaki Tomoyuki Kitazaki Tomoyuki; Akihiro Tasaka; Norikazu Tamura; Yoshihiro 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 2 views

Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro-and 2-Fluorophenyl)-2hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones. -Novel optically active azoles (IX) and (X) ar