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ChemInform Abstract: Optically Active Antifungal Azoles. Part 13. Synthesis of Stereoisomers and Metabolites of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]-3- [4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).

✍ Scribed by Takashi Ichikawa; Masami Yamada; Masashi Yamaguchi; Tomoyuki Kitazaki; Yoshihiro Matsushita; Keiko Higashikawa; Katsumi Itoh

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
33
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Optically Active An
ChemInform Abstract: Optically Active Antifungal Azoles. Part 11. An Alternative Synthetic Route for 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]-3- [4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456) and Its Analogue.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Optically Active An
ChemInform Abstract: Optically Active Antifungal Azoles. Part 7. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2- hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3- tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187).
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Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro-and 2-Fluorophenyl)-2hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones. -Novel optically active azoles (IX) and (X) ar

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## Abstract Starting from the known epoxy alcohol (I), a new strategy for the synthesis of the potent fungicide (IX) in multigram quantities is developed.