𝔖 Bobbio Scriptorium

✦ LIBER ✦

ChemInform Abstract: Optically Active Antifungal Azoles. Part 12. Synthesis and Antifungal Activity of the Water-Soluble Prodrugs of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]-3- [4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone.

✍ Scribed by Takashi Ichikawa; Tomoyuki Kitazaki; Yoshihiro Matsushita; Masami Yamada; Ryogo Hayashi; Masashi Yamaguchi; Yutaka Kiyota; Kenji Okonogi; Katsumi Itoh

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200207253

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Optically Active An

ChemInform Abstract: Optically Active Antifungal Azoles. Part 13. Synthesis of Stereoisomers and Metabolites of 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]-3- [4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456).

✍ Takashi Ichikawa; Masami Yamada; Masashi Yamaguchi; Tomoyuki Kitazaki; Yoshihiro 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

ChemInform Abstract: Optically Active An

ChemInform Abstract: Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones.

✍ Kitazaki Tomoyuki Kitazaki Tomoyuki; Akihiro Tasaka; Norikazu Tamura; Yoshihiro 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 2 views

Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro-and 2-Fluorophenyl)-2hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones. -Novel optically active azoles (IX) and (X) ar

ChemInform Abstract: Optically Active An

ChemInform Abstract: Optically Active Antifungal Azoles. Part 7. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2- hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3- tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187).

✍ A. TASAKA; T. KITAZAKI; N. TSUCHIMORI; Y. MATSUSHITA; R. HAYASHI; K. OKONOGI; K. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

ChemInform Abstract: Optically Active An

ChemInform Abstract: Optically Active Antifungal Azoles. Part 11. An Alternative Synthetic Route for 1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]-3- [4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone (TAK-456) and Its Analogue.

✍ Takashi Ichikawa; Tomoyuki Kitazaki; Yoshihiro Matsushita; Hiroshi Hosono; Masam 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Optically Active An

ChemInform Abstract: Optically Active Antifungal Azoles. Part 10. Synthesis and Antifungal Activity of N-[4-(Azolyl)phenyl]- and N-[4-(Azolylmethyl)phenyl]-N′- [(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]azolones.

✍ Tomoyuki Kitazaki; Takashi Ichikawa; Akihiro Tasaka; Hiroshi Hosono; Yoshihiro M 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

ChemInform Abstract: Synthesis of 2[(1R,

ChemInform Abstract: Synthesis of 2[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3- (1H-1,2,4-triazol-yl)propyl]-4- [4-tetrafluoropropoxyphenyl]-3-(2H,4H)-1,2,4-triazol-3-thione — A Novel and Potent Azole Antifungal Agent.

✍ Jitendra A. Sattigeri; Sachin Sethi; Mohammad Salman 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB

## Abstract Starting from the known epoxy alcohol (I), a new strategy for the synthesis of the potent fungicide (IX) in multigram quantities is developed.