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ChemInform Abstract: Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro- and 2-Fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones.

โœ Scribed by Kitazaki Tomoyuki Kitazaki Tomoyuki; Akihiro Tasaka; Norikazu Tamura; Yoshihiro Matsushita; Hiroshi Hosono; Ryogo Hayashi; Kenji Okonogi; Katsumi Itoh

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro-and 2-Fluorophenyl)-2hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones.

-Novel optically active azoles (IX) and (X) are prepared in a stereocontrolled manner according to the scheme. Compounds (IX) and (X) show potent antifungal activity.

-(KITAZAKI TOMOYUKI; TASAKA, AKIHIRO; TAMURA,

๐Ÿ“œ SIMILAR VOLUMES

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## Abstract Starting from the known epoxy alcohol (I), a new strategy for the synthesis of the potent fungicide (IX) in multigram quantities is developed.