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ChemInform Abstract: Optically Active Antifungal Azoles. Part 7. Synthesis and Antifungal Activity of Stereoisomers of 2-((1R,2R)-2-(2,4-Difluorophenyl)-2- hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3- tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone (TAK-187).

โœ Scribed by A. TASAKA; T. KITAZAKI; N. TSUCHIMORI; Y. MATSUSHITA; R. HAYASHI; K. OKONOGI; K. ITOH


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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Optically Active Antifungal Azoles. Part 8. Synthesis and Antifungal Activity of 1-[(1R,2R)-2-(2,4-Difluoro-and 2-Fluorophenyl)-2hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl] -3-(4-substituted phenyl)-2(1H,3H)-imidazolones and -2-imidazolidinones. -Novel optically active azoles (IX) and (X) ar