𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Preparation of Chiral α-Monofluoroalkylphosphonic Acids and Their Evaluation as Inhibitors of Protein Tyrosine Phosphatase 1B.

✍ Scribed by Christopher C. Kotoris; Wendy Wen; Alan Lough; Scott D. Taylor


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
31
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


ChemInform Abstract: Synthesis and Biolo
✍ Tsutomu Yokomatsu; Tetsuo Murano; Ikuko Umesue; Shinji Soeda; Hiroshi Shimeno; S 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Synthesis and Biological Evaluation of α,α-Difluorobenzylphosphonic Acid Derivatives as Small Molecular Inhibitors of Protein-Tyrosine Phosphatase 1B. -Title compounds (V) and (XI) are prepared by a Stille coupling reaction sequence. It is shown that desired inhibitory activity towards protein-tyro

ChemInform Abstract: Naphthalenebis[α,α-
✍ Q. WANG; Z. HUANG; C. RAMACHANDRAN; A. N. DINAUT; S. D. TAYLOR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Naphthalenebis [α,α-difluoromethylenephosphonates] as Potent Inhibitors of Protein Tyrosine Phosphatases. -The desired disubstituted naphthalenes are better protein tyrosine phosphatase inhibitors than the monosubstituted ones. Derivatives (I)-(III) are the most potent inhibitors yet reported. -(WA