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ChemInform Abstract: Synthesis and Biological Evaluation of α,α-Difluorobenzylphosphonic Acid Derivatives as Small Molecular Inhibitors of Protein-Tyrosine Phosphatase 1B.

✍ Scribed by Tsutomu Yokomatsu; Tetsuo Murano; Ikuko Umesue; Shinji Soeda; Hiroshi Shimeno; Shiroshi Shibuya

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Biological Evaluation of α,α-Difluorobenzylphosphonic Acid Derivatives as Small Molecular Inhibitors of Protein-Tyrosine Phosphatase 1B.

-Title compounds (V) and (XI) are prepared by a Stille coupling reaction sequence. It is shown that desired inhibitory activity towards protein-tyrosine phosphatase 1B correlates with introduced ethynyl, (E)-styryl, phenylethynyl and bismethylsulfonamide groups.

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