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ChemInform Abstract: New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties.

โœ Scribed by Michael S. Malamas; Janet Sredy; Iwan Gunawan; Brenda Mihan; Diane R. Sawicki; Laura Seestaller; Donald Sullivan; Brenda R. Flam


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Biolo
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Synthesis and Biological Evaluation of ฮฑ,ฮฑ-Difluorobenzylphosphonic Acid Derivatives as Small Molecular Inhibitors of Protein-Tyrosine Phosphatase 1B. -Title compounds (V) and (XI) are prepared by a Stille coupling reaction sequence. It is shown that desired inhibitory activity towards protein-tyro