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α,α-Difluoro-β-ketophosphonates as Potent Inhibitors of Protein Tyrosine Phosphatase 1B.

✍ Scribed by Xianfeng Li; Ashok Bhandari; Christopher P. Holmes; Anna K. Szardenings


Publisher
John Wiley and Sons
Year
2004
Weight
24 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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ChemInform Abstract: Naphthalenebis[α,α-
✍ Q. WANG; Z. HUANG; C. RAMACHANDRAN; A. N. DINAUT; S. D. TAYLOR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Naphthalenebis [α,α-difluoromethylenephosphonates] as Potent Inhibitors of Protein Tyrosine Phosphatases. -The desired disubstituted naphthalenes are better protein tyrosine phosphatase inhibitors than the monosubstituted ones. Derivatives (I)-(III) are the most potent inhibitors yet reported. -(WA