ChemInform Abstract: PDE4 Inhibitors: New Xanthine Analogues.
β Scribed by J. G. MONTANA; ET AL. ET AL.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Orally Active Indole N-Oxide PDE4 Inhibitors. -An efficient synthesis to prepare a novel series of potent phosphodiesterase type IV inhibitors (VI) is described. Derivative (VIa) shows a good emetic and pharmacokinetic profile comparable to that of RP73401. -(HULME, CHRISTOPHER; ET