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Discovery of New Orally Active Phosphodiesterase (PDE4) Inhibitors.

โœ Scribed by Hiroshi Ochiai; Akiharu Ishida; Tazumi Ohtani; Kensuke Kusumi; Katuya Kishikawa; Susumu Yamamoto; Hiroshi Takeda; Takaaki Obata; Hisao Nakai; Masaaki Toda


Publisher
John Wiley and Sons
Year
2005
Weight
25 KB
Volume
36
Category
Article
ISSN
0931-7597

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๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Orally Active Indol
โœ Christopher Hulme; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB

Orally Active Indole N-Oxide PDE4 Inhibitors. -An efficient synthesis to prepare a novel series of potent phosphodiesterase type IV inhibitors (VI) is described. Derivative (VIa) shows a good emetic and pharmacokinetic profile comparable to that of RP73401. -(HULME, CHRISTOPHER; ET