✦ LIBER ✦

ChemInform Abstract: Orally Active Indole N-Oxide PDE4 Inhibitors.

✍ Scribed by Christopher Hulme; ET AL. ET AL.

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199911148

No coin nor oath required. For personal study only.

✦ Synopsis

Orally Active Indole N-Oxide PDE4 Inhibitors.

-An efficient synthesis to prepare a novel series of potent phosphodiesterase type IV inhibitors (VI) is described. Derivative (VIa) shows a good emetic and pharmacokinetic profile comparable to that of RP73401. -(HULME, CHRISTOPHER; ET

📜 SIMILAR VOLUMES

ChemInform Abstract: Novel Orally Active

ChemInform Abstract: Novel Orally Active, Dibenzazepinone-Based γ-Secretase Inhibitors.

✍ Jens-Uwe Peters; Guido Galley; Helmut Jacobsen; Christian Czech; Pascale David-P 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Substituted Indoles

ChemInform Abstract: Substituted Indoles as Potent and Orally Active 5-Lipoxygenase Activating Protein (FLAP) Inhibitors.

✍ Richard Frenette; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

ChemInform Abstract: N-1 Substituted Pyr

ChemInform Abstract: N-1 Substituted Pyrimidin-4-ones: Novel, Orally Active Inhibitors of Lipoprotein-Associated Phospholipase A2.

✍ Stephen A. Smith; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

ChemInform Abstract: Synthesis and Struc

ChemInform Abstract: Synthesis and Structure—Activity Relationship of N-Arylrolipram Derivatives as Inhibitors of PDE4 Isozymes.

✍ Thomas H. Keller; Katharine Bray-French; F. W. Joachim Demnitz; Thomas Mueller; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

ChemInform Abstract: Progress Towards th

ChemInform Abstract: Progress Towards the Discovery of Orally Active Thrombin Inhibitors

✍ Keith Menear 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

ChemInform Abstract: Selective, Orally A

ChemInform Abstract: Selective, Orally Active MMP Inhibitors with an Aryl Backbone.

✍ Thomas E. Barta; Daniel P. Becker; Louis J. Bedell; Gary A. De Crescenzo; Joseph 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views