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ChemInform Abstract: 2-Substituted-4-methoxybenzimidazole-Based PDE4 Inhibitors.

✍ Scribed by J. REGAN; ET AL. ET AL.

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

2-Substituted-4-methoxybenzimidazole-Based PDE4 Inhibitors.

-The synthesis of a new family of phosphodiesterase PDE4 inhibitors based on a benzimidazole framework [cf. (VI), (X)] is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease. -(REGAN,

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