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ChemInform Abstract: Lipophilic α-Hydroxybenzylphosphonates as Prodrugs of 3′-Azido-2′ ,3′-dideoxythymidine (AZT).

✍ Scribed by C. MEIER; L. W. HABEL; J. BALZARINI; E. DE CLERCQ


Book ID
112030006
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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Lipophilic α-hydroxybenzylphosphonates a
✍ Meier, Chris ;Habel, Lothar W. ;Balzarini, Jan ;De Clercq, Eric 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 957 KB

## Abstract The α‐hydroxybenzylphosphonates 1a–1j of the antiviral drug 3′‐azido‐2′,3′‐dideoxythymidine 5 (AZT) as potential lipophilic prodrugs were readily accessible in 49% to 87% yield via a four‐step synthetic pathway introducing the modifications in the aromatic ring system in the last step b