Lipophilic α-hydroxybenzylphosphonates a
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Meier, Chris ;Habel, Lothar W. ;Balzarini, Jan ;De Clercq, Eric
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Article
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1995
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John Wiley and Sons
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English
⚖ 957 KB
## Abstract The α‐hydroxybenzylphosphonates 1a–1j of the antiviral drug 3′‐azido‐2′,3′‐dideoxythymidine 5 (AZT) as potential lipophilic prodrugs were readily accessible in 49% to 87% yield via a four‐step synthetic pathway introducing the modifications in the aromatic ring system in the last step b