𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lipophilic 5′,5′-O-Dinucleoside-α-hydroxybenzylphosphonic Acid Esters as Potential Prodrugs of 2′,3′-Dideoxythymidine (ddT)

✍ Scribed by Dr. Chris Meier


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
360 KB
Volume
32
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


5′,5′-O-Dinucleosid-α-hydroxybenzylphosp
✍ Dr. Chris Meier 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 387 KB

genwart der DSNP-Gruppe (11 + 5c) ebenfalls nur eine geringfiigige Verbesserung. Moglicherweise liegt die Ursache fur diese ,,Sattigung" jedoch in der Durchfuhrung des Enzymassays, bei dem das Enzym durch sehr starke Inhibitoren titriert wird. Wie envartet, ist die inhibitorische Wirkung auch stark

5′,5′-di-O-nucleosyl-O′-benzylphosphotri
✍ Meier, Chris ;Habel, Lothar W. ;Balzarini, Jan ;De Clercq, Eric 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 753 KB

## Abstract The synthesis of 5′,5′‐__O__‐di‐(3′‐azido‐2′,3′‐dideoxythymidinyl)‐__O__′‐benzylphosphotriesters 1 as potential prodrugs of nucleoside monophosphates is described. The concept is applied to the antiretroviral nucleoside analog 3′‐azido‐2′,3′‐deoxythymidine (AZT) 4. All derivatives 1 wer

ChemInform Abstract: Synthesis, in vitro
✍ K. PARANG; E. E. KNAUS; L. I. WIEBE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

Synthesis, in vitro anti-HIV Activity, and Biological Stability of 5'-O-Myristoyl Analogue Derivatives of 3'-Fluoro-2',3'-dideoxythymidine (FLT) as Potential Bifunctional Prodrugs of FLT. -Among several derivatives of the highly active FLT (Ia), the analogues (Ib) and (Ie) are found to be the most e