## Abstract The α‐hydroxybenzylphosphonates 1a–1j of the antiviral drug 3′‐azido‐2′,3′‐dideoxythymidine 5 (AZT) as potential lipophilic prodrugs were readily accessible in 49% to 87% yield via a four‐step synthetic pathway introducing the modifications in the aromatic ring system in the last step b
✦ LIBER ✦
The 5′-Hydrogen Phosphonate Analog as a Potential Prodrug of 3′-Azido-2′,3′-dideoxythymidine (AZT)
✍ Scribed by Boal, Jila H.; Iyer, Radhakrishnan P.; Egan, William
- Book ID
- 115496258
- Publisher
- Taylor and Francis Group
- Year
- 1993
- Tongue
- English
- Weight
- 500 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0732-8311
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## Abstract The synthesis of 5′,5′‐__O__‐di‐(3′‐azido‐2′,3′‐dideoxythymidinyl)‐__O__′‐benzylphosphotriesters 1 as potential prodrugs of nucleoside monophosphates is described. The concept is applied to the antiretroviral nucleoside analog 3′‐azido‐2′,3′‐deoxythymidine (AZT) 4. All derivatives 1 wer