✦ LIBER ✦

Intracellular metabolism and pharmacokinetics of 5′-hydrogenphosphonate of 3′-azido-2′,3′-dideoxythymidine, a prodrug of 3′-azido-2′,3′-dideoxythymidine

✍ Scribed by Yurii Skoblov; Inna Karpenko; Elena Shirokova; Konstantin Popov; Valerya Andronova; Georgii Galegov; Marina Kukhanova

Book ID: 113457125
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 155 KB
Volume: 63
Category: Article
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2004.03.001

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of 2′-Azido-2′,3′-didehydro-2′

Synthesis of 2′-Azido-2′,3′-didehydro-2′,3′-dideoxythymidine

✍ Mikhailopulo, Igor A. ;Zaitseva, Galina V. ;Vaaks, Elena V. ;Balzarini, Jan ;De 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

## Abstract Compound 15 – the 2′‐azido analog of the anti‐HIV compound 2′,3′‐didehydro‐2′,3′‐dideoxythymidine – was synthesized. Treatment of 5′‐__O__‐trityl‐β‐D‐ribofuranosylthymine (1) with DAST or MSTF gave the 2,2′‐anhydro derivative 2. The latter and its 3′‐__O__‐benzoate 3 were used for the s

Pharmacokinetics and Tissue Distribution

Pharmacokinetics and Tissue Distribution of (±)-3′-Azido-2′,3′-dideoxy-5′-O-(2-bromomyristoyl)thymidine, a Prodrug of 3′-Azido-2′,3′-dideoxythymidine (AZT) in Mice

✍ Keykavous Parang; Leonard I. Wiebe; Edward E. Knaus 📂 Article 📅 1998 🏛 Pharmaceutical Press 🌐 English ⚖ 732 KB

Metabolism and activities of 3′-azido-2′

Metabolism and activities of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-didehydro-2′,3′-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes

✍ Richard R Drake; Robyn McMasters; Stephanie Krisa; Steven D Hume; Tammy M Rechti 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 187 KB

The 5′-Hydrogen Phosphonate Analog as a

The 5′-Hydrogen Phosphonate Analog as a Potential Prodrug of 3′-Azido-2′,3′-dideoxythymidine (AZT)

✍ Boal, Jila H.; Iyer, Radhakrishnan P.; Egan, William 📂 Article 📅 1993 🏛 Taylor and Francis Group 🌐 English ⚖ 500 KB

Lipophilic α-hydroxybenzylphosphonates a

Lipophilic α-hydroxybenzylphosphonates as prodrugs of 3′-azido-2′,3′-dideoxythymidine (AZT)

✍ Meier, Chris ;Habel, Lothar W. ;Balzarini, Jan ;De Clercq, Eric 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 957 KB

## Abstract The α‐hydroxybenzylphosphonates 1a–1j of the antiviral drug 3′‐azido‐2′,3′‐dideoxythymidine 5 (AZT) as potential lipophilic prodrugs were readily accessible in 49% to 87% yield via a four‐step synthetic pathway introducing the modifications in the aromatic ring system in the last step b

Synthesis and anti-HIV activities of pho

Synthesis and anti-HIV activities of phosphate triester derivatives of 3′-fluoro-2′,3′-dideoxythymidine and 3′-azido-2′,3′-dideoxythymidine

✍ Hitesh K. Agarwal; Gustavo F. Doncel; Keykavous Parang 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 169 KB

Fatty acyl-glycol phosphate triester conjugates of 3 0 -fluoro-2 0 ,3 0 -dideoxythymidine (FLT) were prepared in three steps from the reaction of diisopropylphoramidous dichloride with fatty acyl-substituted glycols, followed by a coupling reaction with FLT and oxidation with tert-butyl hydroperoxid