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ChemInform Abstract: 5′,5′-Di-O-nucleosyl-O′-benzylphosphotriesters as Potential Prodrugs of 3′-Azido-2′,3′-dideoxythymidine-5′-monophosphate.

✍ Scribed by C. MEIER; L. W. HABEL; J. BALZARINI; E. DE CLERCQ


Book ID
112030007
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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5′,5′-di-O-nucleosyl-O′-benzylphosphotri
✍ Meier, Chris ;Habel, Lothar W. ;Balzarini, Jan ;De Clercq, Eric 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 753 KB

## Abstract The synthesis of 5′,5′‐__O__‐di‐(3′‐azido‐2′,3′‐dideoxythymidinyl)‐__O__′‐benzylphosphotriesters 1 as potential prodrugs of nucleoside monophosphates is described. The concept is applied to the antiretroviral nucleoside analog 3′‐azido‐2′,3′‐deoxythymidine (AZT) 4. All derivatives 1 wer