5′,5′-di-O-nucleosyl-O′-benzylphosphotri
✍
Meier, Chris ;Habel, Lothar W. ;Balzarini, Jan ;De Clercq, Eric
📂
Article
📅
1995
🏛
John Wiley and Sons
🌐
English
⚖ 753 KB
## Abstract The synthesis of 5′,5′‐__O__‐di‐(3′‐azido‐2′,3′‐dideoxythymidinyl)‐__O__′‐benzylphosphotriesters 1 as potential prodrugs of nucleoside monophosphates is described. The concept is applied to the antiretroviral nucleoside analog 3′‐azido‐2′,3′‐deoxythymidine (AZT) 4. All derivatives 1 wer