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ChemInform Abstract: cis-2-Amino-1-acenaphthenol: Practical Resolution and Application to the Catalytic Enantioselective Reduction of Ketones.

โœ Scribed by A. SUDO; M. MATSUMOTO; Y. HASHIMOTO; K. SAIGO


Book ID
112024644
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: cis-1-Amino-1,2,3,4
โœ S. HIGASHIJIMA; H. ITOH; Y. SENDA; S. NAKANO ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 28 KB ๐Ÿ‘ 1 views

cis-1-Amino-1,2,3,4-tetrahydro-2-naphthalenol: Resolution and Application to the Catalytic Enantioselective Reduction of Ketones. -The optically active title amino alcohols are prepared by optical resolution of racemic amino alcohols with (-)-mandelic acid and used in the asymmetric reduction of ke

The chiral amino alcohol, cis-2-amino-1-
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The cbiral amino alcohol, cis-Zamino-1-acenaphthenol, was synthesized, and resolved by a simple procedure. This new chiral amino alcohol was converted into an oxaxoline derivative and applied as a chiral auxiliary to the diastereoselective (2.3]-Wittig rearrangement.

Suitably designed chiral amino alcohols:
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The amino alcohol rac-1-(1,2,3,4-tetrahydroisoquinoline-1-yl)-cyclopentanol was resolved via its O,O'-dibenzoyl-tartaric acid salt. These enantiomeric amino alcohols were used in the enantioselective reduction of prochiral aryl alkyl ketones. The resulting secondary alcohols were obtained in high en