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Characterisation of denervation supersensitivity in the striatonigral gam pathway of the kainic acil-lesioned rat and in huntington's disease

✍ Scribed by Waddington, John L.; Cross, Alan J.

Book ID: 122826673
Publisher: Elsevier Science
Year: 1979
Tongue: English
Weight: 158 KB
Volume: 4
Category: Article
ISSN: 0361-9230
DOI: 10.1016/0361-9230(79)90185-0

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by “norm