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Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease

✍ Scribed by D Joel; L Ayalon; R Tarrasch; L Veenman; J Feldon; I Weiner

Book ID
114003520
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
1000 KB
Volume
787
Category
Article
ISSN
0006-8993

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Deficits induced by quinolinic acid lesi
Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: A potential novel treatment in a rat model of Huntington's disease
✍ Daphna Joel; Liat Ayalon; Ricardo Tarrasch; Ina Weiner πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 241 KB πŸ‘ 1 views

## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by β€œnorm