Kainic acid lesions of the striatum in rats mimic the spontaneous motor abnormalities of Huntington's disease
โ Scribed by S.T. Mason; H.C. Fibiger
- Book ID
- 118954074
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 429 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0028-3908
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Ganglioside and DNA levels were estimated in the striatum of rats 10 days and 6 weeks after lesioning by intrastriatal injection of kainic acid. There was a moderate, 21-24% decrease of the ganglioside concentration per unit protein on the side of the lesion, which can be ascribed to the loss of the
Spontaneous recurrent seizures (SRSs) were observed in female rats following the injection of kainic acid into the dorsal hippocampus. Pregnancy and nursing decreased the frequency of SRSs in such animals. The finding of a protective effect of pregnancy and lactation in this animal model of temporal