✦ LIBER ✦

Pregnancy decreases the frequency of spontaneous recurrent seizures in rats with kainic acid lesions of the hippocampus

✍ Scribed by Maria Da Penha P. Berzaghi; Debora Amado; Esper A. Cavalheiro

Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 208 KB
Volume: 1
Category: Article
ISSN: 0920-1211
DOI: 10.1016/0920-1211(87)90021-0

No coin nor oath required. For personal study only.

✦ Synopsis

Spontaneous recurrent seizures (SRSs) were observed in female rats following the injection of kainic acid into the dorsal hippocampus. Pregnancy and nursing decreased the frequency of SRSs in such animals. The finding of a protective effect of pregnancy and lactation in this animal model of temporal lobe epilepsy stresses the usefulness of this model.

📜 SIMILAR VOLUMES

Intracellular electrophysiology of CA1 p

Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat

✍ T. J. Ashwood; B. Lancaster; H. V. Wheal 📂 Article 📅 1986 🏛 Springer-Verlag 🌐 English ⚖ 844 KB

Intracellular recordings were made from hippocampal CA1 pyramidal cells in slices where the CA3/CA4 region had been lesioned using intracerebroventricular kainic acid. In 55% of the cells studied orthodromic excitation evoked bursts of action potentials. This bursting activity was associated with a