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AAV-BDNF augments neurogenesis in both the normal adult rat brain and the quinolinic acid lesion model of Huntington's disease

✍ Scribed by B. Connor; R.A. Henry; R.L.M. Faull; S.M. Hughes


Book ID
116458796
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
53 KB
Volume
198
Category
Article
ISSN
0014-4886

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by β€œnorm