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Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology

✍ Scribed by S. Kar; J. Poirier; J. Guevara; D. Dea; C. Hawkes; Y. Robitaille; R. Quirion


Book ID
116780666
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
926 KB
Volume
27
Category
Article
ISSN
0197-4580

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Insulin-induced redistribution of the in
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The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act