Brain injury has been prevented recently by systemic administration of human insulin-like growth factor-I (hIGF-I). It is widely believed that protein neurotrophic factors do not enter the brain from blood, and the mechanism by which circulating hIGF-I may be neuroprotective is uncertain. This inves
โฆ LIBER โฆ
Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and Alzheimer disease brains
โ Scribed by S. Jafferali; Y. Dumont; F. Sotty; Y. Robitaille; R. Quirion; S. Kar
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 352 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0887-4476
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The human insulin analogue ASPB 10 has been reported to have increased affinity for the insulin receptor and to cause breast cancer in female rats. In the study reported here, we investigated whether ASPB 10 has an increased mitogenic potency and induces a transformed phenotype in cultured human bre