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Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes

✍ Scribed by Nilani Jeyaratnaganthan; Kurt Højlund; Jens Peter Kroustrup; Jens Fromholt Larsen; Mette Bjerre; Klavs Levin; Henning Beck-Nielsen; Susana Frago; A. Bassim Hassan; Allan Flyvbjerg; Jan Frystyk


Book ID
116512354
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
359 KB
Volume
20
Category
Article
ISSN
1096-6374

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The soluble form of the insulin-like growth factor II (IGF-II)/mannose 6-P (IGF-II/ M6P) receptor is released by cells in culture and circulates in the serum. It retains its ability to bind IGF-II and blocks IGF-II-stimulated DNA synthesis in isolated rat hepatocytes. Because these cells are not nor