Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2 receptor
β Scribed by Li, Jin; Sahagian, G Gary
- Book ID
- 110069104
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 409 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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M6P/IGF2R encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and cytotoxic T cell-induced apoptosis. M6P/IGF2R is imprinted and expressed only from the maternally inherited allele in marsupials and rodents. In contrast, humans were ini
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