M6P/IGF2R encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and cytotoxic T cell-induced apoptosis. M6P/IGF2R is imprinted and expressed only from the maternally inherited allele in marsupials and rodents. In contrast, humans were ini
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene
โ Scribed by Adam J. Oates; Lisa M. Schumaker; Sara B. Jenkins; Amelia A. Pearce; Stacey A. DaCosta; Banu Arun; Matthew J.C. Ellis
- Book ID
- 110230817
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 879 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0167-6806
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The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) suppresses cell growth through binding to the insulin-like growth factor 2 (IGF2) and latent complex of the transforming growth factor-โค (TGF-โค). Recently, it was reported in the United States that loss of heterozygosity (LOH)
The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-IIR) is thought to act as a suppressor of tumor growth by binding the mitogenic peptide IGF-II and modulating its extracellular levels via degradation. This receptor has been found to be absent or nonfunctional in a high proport