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A common polymorphism in exon 40 of the human mannose 6-phosphate/insulin-like growth factor II receptor gene

✍ Scribed by X Zhong; H Hemmi; H Shimatake


Book ID
115638330
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
147 KB
Volume
13
Category
Article
ISSN
0890-8508

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The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act