Developmental regulation of insulin-like growth factor-II/mannose 6-phosphate receptor mRNA in the rat
β Scribed by Mercedes Ballesteros; Carolyn D. Scott; Robert C. Baxter
- Book ID
- 115762907
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 412 KB
- Volume
- 172
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act
The soluble form of the insulin-like growth factor II (IGF-II)/mannose 6-P (IGF-II/ M6P) receptor is released by cells in culture and circulates in the serum. It retains its ability to bind IGF-II and blocks IGF-II-stimulated DNA synthesis in isolated rat hepatocytes. Because these cells are not nor